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The manipulation of cellular function, such as the regulation of gene expression, is of great interest to many biotechnological applications and often achieved by the addition (…)

Authors: Kusen, Peter M.; Wandrey, Georg; Krewald, Vera; Holz, Martina; zu Berstenhorst, Sonja Meyer; Buechs, Jochen; Pietruszka, Joerg

Journal: Journal of Biotechnology, Volume: 258, Pages: 117-125

BACKGROUND
Escherichia coli is often used for recombinant protein production. The expression of recombinant proteins negatively affects the microbial growth, thus, a ba (…)

Authors: Ladner, Tobias; Muehlmann, Martina; Schulte, Andreas; Wandrey, Georg; Buechs, Jochen

Journal: Journal of Biological Engineering, Volume: 11

In recent years, researchers have explored the application of Reinforcement Learning (RL) and Artificial Neural Networks (ANNs) to the control of complex nonlinear and time va (…)

Authors: Pandian, B. Jaganatha; Noel, Mathew Mithra

Journal: Journal of Process Control (2018), Volume: 69, Pages: 16-29

In order to examine the structure–activity relationship and the substrate specificity of human d-amino acid oxidase (h.DAO), a single amino acid mutation had been established (…)

Authors: Abou El-Magd, Rabab M.; Sasaki, Chizuru; Kawazoe, Tomoya; El-Sayed, Salah M.; Yorita, Kazuko; Shishido, Yuji; Sakai, Takash; Nakamura, Yoshitoshi; Fukui, Kiyoshi

Journal: Biochemical Engineering Journal, Volume: 52, Issue: 2-3, Pages: 236-247

Small‐scale upstream bioprocess development often occurs in flasks and multi‐well plates. These culturing platforms are often not equipped to accurately monitor and control cr (…)

Authors: Hanson, Michael A.; Ge, Xudong; Kostov, Yordan; Brorson, Kurt A.; Moreira, Antonio R.; Rao, Govind

Journal: Biotechnology and Bioengineering, Volume: 97, Issue: 4, Pages: 833-841

AIMS
The objective of this study is to optimize the levels of carbon and nitrogen sources of the medium in shake flask experiments and evaluate the effect of pH and dis (…)

Authors: Agarwal, A.; Kumar, S.; Veeranki, V. D.

Journal: Letters in Applied Microbiology, Volume: 52, Issue: 4, Pages: 307-313

High-throughput bioprocessing is a very promising technique for bioprocess development and optimization because of its high efficiency. The key to its development has been the (…)

Authors: Ge, Xudong; Kostov, Yordan; Rao, Govind

Journal: Biotechnology and Bioengineering, Volume: 89, Issue: 3, Pages: 329-334

Extended cultivation times, rendering phototrophic bioprocess development time inefficient, resulted in the recent development of micro-photobioreactors enabling accelerated p (…)

Authors: Morschett, Holger; Schiprowski, Danny; Rohde, Jannis; Wiechert, Wolfgang; Oldiges, Marco

Journal: Bioprocess and Biosystems Engineering, Volume: 40, Issue: 5, Pages: 663–673

Filamentous organisms of the genus Streptomyces play an important role in industrial production processes, due to their extensive secondary metabolism variability, as well as (…)

Authors: Koepff, Joachim; Keller, Matthias; Tsolis, Konstantinos C.; Busche, Tobias; Rueckert, Christian; Hamed, Mohamed B.; Anne, Jozef; Kalinowski, Joern; Wiechert, Wolfgang; Economou, Anastassios

Journal: Biotechnology and Bioengineering, Volume: 114, Issue: 9, Pages: 2011-2022

Small-scale high-throughput screening devices are becoming increasingly important in bioprocess development. Conventional dipping probes for process monitoring are often too l (…)

Authors: Ladner, Tobias; Beckers, Mario; Hitzmann, Bernd; Buechs, Jochen

Journal: Biotechnology Journal, Volume: 11, Issue: 12, Pages: 1605-1616

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