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The yeast Pichia pastoris is a widely used host for the secretion of heterologous proteins. Despite being an efficient producer, we observed previously that (…)

Authors: Marsalek, Lukas; Puxbaum, Verena; Buchetics, Markus; Mattanovich, Diethard; Gasser, Brigitte

Journal: Microbial Cell Factories

The increasing demand for biopharmaceuticals produced in mammalian cells has driven the industry to enhance the productivity of bioprocesses through intensification of culture (…)

Authors: Martínez-Monge, Iván; Roman Roldan, Ramon; Fontova, Andreu; Lecina, Marti; Casablancas, Antoni; Cairó, J. J

Journal: Applied Microbiology and Biotechnology

Expanding the application of technical enzymes, e.g., in industry and agriculture, commands the acceleration and cost-reduction of bioprocess development. Mi (…)

Authors: Alexander Eck; Matthias Schmidt; Stefanie Hamer; Anna Joelle Ruff; Jan Förster; Ulrich Schwaneberg; Lars M. Blank; Wolfgang Wiechert; Marco Oldiges

Journal: Fungal Biology and Biotechnology (2018)

Bioprocesses operated in batch mode can induce adverse effects like overflow metabolism, substrate inhibition, osmotic inhibition, oxygen limitation and catabolite repression. (…)

Authors: Tobias Habicher, Vroni Czotscher, Tobias Klein, Andreas Daub, Timm Keil, Jochen Büchs

Journal: Biotechnology Bioengineering

The use of benchtop bioreactors (BRs) for the development of mammalian cell perfusion cultures is expensive and time consuming, given its complexity in equipment and operation (…)

Authors: Wolf, Moritz K. F.; Lorenz, Veronika; Karst, Daniel J.; Souquet, Jonathan; ] ; Karst, DJ (Karst, Daniel J.)[ 1 ] ; Souquet, J (Souquet, Jonathan)[ 2 ] ; Broly, H (Broly, Herve; Morbidelli, Massimo

Journal: Biotechnology and Bioengineering, Volume: 115, Issue: 11, Pages: 2703-2713

The cell‐specific growth rate (µ) is a critical process parameter for antibody production processes performed by animal cell cultures, as it describes the cell growth and refl (…)

Authors: Li, Meng-Yao; Ebel, Bruno; Blanchard, Fabrice; Paris, Cedric; Guedon, Emmanuel; Marc, Annie

Journal: Biotechnology and Bioengineering, Volume: 116 Issue: 5, Pages: 985-993

This chapter about single‐use bioreactors (SUBs) aims to provide an overview of the advances in this – compared with conventional bioreactors – young field of bioreactor devel (…)

Authors: Nico M.G. Oosterhuis; Stefan Junne

Journal: Bioreactors: Design, Operation and Novel Applications

The Gram-negative bacterium E. coli is the host of choice for the production of a multitude of recombinant proteins in industry. Generally, cultivation is easy, media are chea (…)

Authors: Slouka, Christoph; Kopp, Julian; Strohmer, Daniel; Kager, Julian; Spadiut, Oliver; Herwig, Christoph

Journal: Journal of Biotechnology, Volume: 296, Pages: 75-82

To overcome catabolite repression, industrial fermentation processes are usually operated in substrate‐limited fed‐batch mode. Therefore, the implementation of such an operati (…)

Authors: Tobias Habicher; Arian John; Niklas Scholl; Andreas Daub; Tobias Klein; Priya Philip; Jochen Büchs

Journal: Biotechnology and Bioengineering

The application of standard sensor electrodes is often limited to stirred tank reactors due to their wired nature and their large space requirement. For other cultivation syst (…)

Authors: Tim Lauterbach; Tobias Lüke; Maik-Julian Büker; Christian Hedayat; Tassilo Gernandt; Rüdiger Moll; Michael Grösel; Stephan Lenk; Franziska Seidel; Dietmar Brunner; Thomas Bley; Thomas Walther; Felix Lenk

Journal: Sensors and Actuators A: Physica, Volume: 287

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