large scale
Is it possible to incubate larger bioreactors than shake flasks on an orbital shaker?


In the literature you can find several examples for orbital shaking of volumes up to 1500 L, mostly in the field of mammalian and plant cell culture:
Novel Orbital Shake Bioreactors for Transient Production of CHO Derived IgGs
Stettler M, Zhang X, Hacker DL, De Jesus M, Wurm FM
Biotechnol. Prog., 2007, Vol. 23, No. 6, pp 1340 -1346


Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 L by surface aeration with air
Zhang X, Stettler M, Reif O, Kocourek A, Dejesus M, Hacker DL, Wurm FM
New Biotechnology, 2008, Vol. 25, No. 1, pp 68-75


Large-scale disposable shaking bioreactors: A promising choice
Raval K., Liu C.-M., Buechs J.
BioProcess International, 2006, Vol. 4, No. 1, pp 46-49

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